Immunologic and Microbial Correlates and Mechanisms of Complete Response to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer
Abstract
Bladder cancer is often treated with cisplatin-based chemotherapy. Based on our preliminary data, we believe that the immune system has a significant impact on the responder status outcome of patients receiving chemotherapy. We localized this putative immune response to chemotherapy to the CD8 effector T cells. To further characterize this response, we will be quantifying the cytotoxicity and expression profile from perivesical lymph nodes. In addition, we will experimentally test the possibility that CD8 effector T cells impact the chemoresponse using orthotopic bladder cancer mouse models. We have also identified a microbiome within tumors and within urine samples from bladder cancer patients which may further impact the responder status. We will compare the tumor and urine microbiomes of patients receiving chemotherapy to determine their overlap and their associations with response. We will then test these correlations in an orthotopic bladder cancer mouse model to determine if these are merely correlations or causative of response. It is also possible that we will uncover connections between the microbiome and immune system that further are causative of chemoresponse or chemoresistance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2022
- Accession Number
- AD1207969
Entities
People
- Philip Abbosh
Organizations
- Fox Chase Cancer Center