Impact of Tau Protein Deposition in Parkinson's Disease
Abstract
A cohort of cognitively normal Parkinson's disease (PD), cognitively impaired PD, and dementia with Lewy bodies (DLB) subjects were recruited and underwent MRI, amyloid PET, and tau PET imaging, together with cognitive testing and neurological evaluation. Participants were assessed at baseline and after at least one year. There was a significant overlap in the regional pattern of cortical thinning between DLB and PDD, extending beyond the Alzheimer's signature to include the fusiform and precentral gyrus. Regional thinning was detectable in amyloid negative DLB but not cognitively impaired PD. Amyloid deposition was associated with increased cortical atrophy in both DLB and cognitively impaired PD. Across diagnostic groups, baseline amyloid burden was associated with faster longitudinal cognitive decline but was not related to longitudinal cortical thinning. Baseline tau burden was associated with longitudinal cognitive decline but was not related to longitudinal cortical thinning. Longitudinal cortical thinning was not associated with the rate of cognitive decline.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2023
- Accession Number
- AD1207982
Entities
People
- John Growdon
- Joseph Locascio
- Keith Johnson
- Stephen N. Gomperts
Organizations
- Massachusetts General Hospital