Early Screening and Diagnosis for Low Bone Mineral Density Utilizing Opportunistic Screening, Serum Biomarkers, and Advanced Modeling

Abstract

This is a 5-year, prospective cohort study of Hounsfield Unit (HU) and Fracture Risk, to determine whether HU obtained from existing CT scans is associated with BMD by DEXA, serum levels of bone turnover markers, and long term risk fractures. Tow arms of this cohort will be recruited; a small cohort will receive a DEXA scan, serum biomarker testing, and prospective fracture monitoring, while a larger cohort will simply be enrolled for prospective fracture monitoring alone for two years. Patients in the second cohort will be categorized as osteoporotic, osteopenic, and normal BMD as determined by HU values as they are enrolled into the study. The study is being conducted at Walter Reed National Military Medical Center and the Uniformed Services University of the Health Sciences.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2023
Accession Number
AD1209092

Entities

People

  • Scott M. Tintle

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Biological Markers
  • Data Analysis
  • Data Mining
  • Data Science
  • Department Of Defense
  • Fragility
  • Information Science
  • Medical Personnel
  • Military Medicine
  • Monitoring
  • Osteoporosis
  • Predictive Modeling
  • Spinal Column
  • Spine
  • Standards
  • Statistical Analysis
  • Storage
  • Students
  • Universities
  • Vitamin D
  • X-Ray Computed Tomography

Fields of Study

  • Medicine

Readers

  • Exercise and Sports Science.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Medical Imaging.