Treatment of Spinal Cord Ischemia with Cell Impermeant-Based Resuscitation
Abstract
Spinal Cord Injury (SCI) is a serious problem for warfighters injured in far forward areas. Progressive spinal cord tissue swelling secondary to closed trauma aggravate the initial injury. A new low volume resuscitation (LVR) platform using cell impermeant polymers protects systemic tissues after trauma and ischemia by reversing and preventing lethal cell and tissue metabolic swelling. This improves microcirculation and oxygen delivery early after injury. The aim of this project was to test this strategy in SCI in rodents. First, polyethylene glycol (PEG) polymers were sized to optimize use in the spinal cord since the capillary permeability is different. A cocktail of PEG-2k, -5k, and -20k was developed and used in rodent SCI studies. The crystalloid used after injury suppressed tissue swelling and inflammation but failed to affect motor outcomes over 60 days after injury. Return of function of neurogenic bladder was accelerated. Additional dosing, which was deemed needed, produced a study limiting gastroparesis not seen in swine. Although this study was negative, we believe additional doses would produce better outcomes and has potential use in humans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2021
- Accession Number
- AD1209093
Entities
People
- Martin J Mangino
Organizations
- Virginia Commonwealth University