Prevention of the Post-Traumatic Fibrotic Response in Joints: A Critical Preclinical Evaluation of an Antifibrotic Antibody

Abstract

The main objective of this project is to help wounded soldiers to recover from injuries to their extremities by applying a therapeutic antibody to reduce posttraumatic joint stiffness. Since clinical interventions available today to limit post-traumatic joint stiffness are sparse and their outcomes are disappointing, our research is needed and timely. The soldiers are uniquely prone to suffer from joint injuries due to the risks associated with their military activities. One of the significant complications of trauma to the joints is post-traumatic joint stiffness that severely limits the range of motion, causes pain, and makes it impossible to resume military duties. Posttraumatic joint stiffness mainly results from the formation of scar tissue that alters the normal function of injured joints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2023
Accession Number
AD1209094

Entities

People

  • Andrzej Fertala

Organizations

  • Thomas Jefferson University

Tags

DTIC Thesaurus Topics

  • Blood
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Connective Tissue
  • Culture Techniques
  • Health Services
  • Jointsanatomy
  • Lung Diseases
  • Mechanical Properties
  • Medical Personnel
  • Orthopedic Surgical Procedures
  • Orthopedics
  • Rodents
  • Therapy
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Educational Psychology
  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.