Repair of Traumatized Muscle Tissue for Improvement of Musculoskeletal Healing
Abstract
In this proposal we hypothesized that using a minced skeletal muscle autorgraft to fill a volumetric muscle defect in Yucatan Minipigs subjected to a segmental bone defect (SBD) combined with volumetric muscle loss (VML) would 1) improve fracture healing of the SBD; and 2) improve muscle function. We have operated on 5 pigs with isolated SBD; 7 pigs with SBD combined with VML; and 5 pigs with SBD and VML treated with minced skeletal muscle autograft (SMA). Our findings showed that SMA improved bone healing achieving union in 3 of 4 pigs and currently the 5th pig is on a healing trajectory. In contrast 5 of 6 VML pigs have developed nonunions and the 7th pig is still under evaluation. SMA has not improved muscle function at the time of sacrifice at 3 months but muscle strength was still improving in SMA pigs compared to VML pigs. In summary, SMA improved bone healing and may improve muscle function. Detailed biochemical and histological analysis of the tissue will be conducted during a no-cost extension period from 11.1.2019 to 10.31.2020.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2021
- Accession Number
- AD1209099
Entities
People
- Todd O McKinley
Organizations
- Indiana University Bloomington