Low-Cost, High-Throughput 3D Pulmonary Imaging Using Hyperpolarized Propane Gas
Abstract
This report covers the third year of the project. During the indicated period of performance, we have focused our activities primarily on two (out of three) specific aims. With regards to Aim #1 (to develop a clinical low-cost and high-throughput device for production and administration of HP propane contrast agent for ultimate research use in volunteers), we have continued working on testing the robustness of the portable propane hyperpolarizer device. The device has been tested for its efficacy at the clinically relevant conditions of 1 atm pressure in phantoms and the excised pig lungs. While the progress of working on all aims of this project has been substantially impacted by the COVID-19 pandemic, this year we made substantial progress towards Aim #3 (To assess the feasibility of MRI using HP propane gas for in vivo functional imaging of normal lungs and in a bleomycin induced COPD model in sheep) - specifically, we have established fast imaging protocols on 0.35 T clinical MRI scanner (for both HP 129Xe gas and HP propane gas), completed personnel training, and performed a wide range of 0.35 T MRI imaging studies at WSU. Moreover, the partnering site (SIUC), having previously completed installation of a portable MRI scanner and demonstrated its utility for hyperpolarized proton MRI on small scales, has worked to scale up this capability by a factor of approx. 30.Moreover, following training at WSU, a HP propane capability has now been installed at SIUC for ongoing HP NMR/MRI studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2023
- Accession Number
- AD1209550
Entities
People
- Boyd M Goodson
- Eduard Y. Chekmenev
Organizations
- Southern Illinois University Carbondale