Steroid-Eluting Therapeutic Contact Lens to Treat and Prevent Inflammation and Scarring Following Ocular Trauma
Abstract
Steroids are frequently used in the care of ocular inflammation, for both post injury and postoperative care. In our previous work with the DOD, we developed a dexamethasone-eluting contact lens continuously worn on the eye which dispenses drug for seven days. Here, we seek to perform further efficacy testing, physicochemical characterization of the TCL, and transfer production to a GLP facility, followed by formal biocompatibility testing in a GLP lab. We demonstrated the TCL can prevent retinal vascular leakage in an animal model. Technology transfer to a GLP facility for fabrication has continued.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1209655
Entities
People
- Joseph B Ciolino
Organizations
- Schepens Eye Research Institute