Gulf War Illness Susceptibility and Gut Microbiome Dysbiosis: A Search for Biomarkers to Boost Resilience

Abstract

Treatment with Gulf War Illness (GWI) agents resulted in gut microbiome alterations that translated into a differential expression of bacterial metabolites. Furthermore, these differences were evident within the GWI-susceptible group when compared to controls and with GWI-resilient subjects. Among the overall changes, a decrease in the amount of 3 major short chain fatty acids (SCFAs) including butyrate was found in GWI-susceptible animals, along with decreases in bile acids. Supplementation of butyrate was tested for its hypothesized capacity to balance the gut microbiome homeostasis and we evaluated its effects at the behavioral and bacterial composition levels. Butyrate was administered to animals that developed GWI symptoms and showed to be effective in ameliorating gastrointestinal alterations, pain sensitivity and cognitive impairments. This capacity of butyrate was associated with its ability to restore the gut microbiome composition to the one of controls.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2023
Accession Number
AD1209671

Entities

People

  • Mariana Angoa-pĂ©rez

Organizations

  • Wayne State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bacteria
  • Bile
  • Biological Markers
  • Biomedical Research
  • Butyrates
  • Cognitive Impairment
  • Discriminant Analysis
  • Dysbiosis
  • Fatty Acids
  • Governments
  • Gut Microbiome
  • Local Governments
  • Metabolites
  • Microbiomes
  • Persian Gulf Syndrome
  • Platforms
  • Resilience
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular Biology and Genetics