How Do Coupled Noncovalent Forces Affect the Properties of Complex Structures?
Abstract
This proposal outlined an experimental plan for characterizing how perturbations in a noncovalent network of coupled interactions were accommodated by the structures network. Such questions are fundamental to the properties of complex materials such as proteins, polymers, and many other entities. Preliminary evidence suggested that such distortions were minimized by a combination of enthalpic and entropic response mechanisms. The research plan focused on delineating how both the structure and dynamics responded to changes in the noncovalent network of a complex [2]-catenane model. This model provided enough complexity to create a functioning noncovalent network, but was sufficiently manipulable and characterizable to extract high-resolution structure-property relationships for mutated variants. The outcome of these efforts were molecular level descriptions of how non-covalent networks can facilitate structural changes and stabilize insults to their structure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 06, 2022
- Accession Number
- AD1209681
Entities
People
- Stephen J. Lee
Organizations
- University of North Carolina at Chapel Hill