Complex Orbital Reconstruction
Abstract
1. The number and severity of battlefield injuries to the craniofacial region increased significantly with the operations in Iraq and Afghanistan as has thesurvival of personnel with hemifacial injuries after ballistic trauma. Non-battlefield craniofacial injuries, including blunt trauma from motor vehicle accidentsand falls, also provide a significant challenge in military operations and are relevant to the general population. Because of the complex nature of theseinjuries and the location in the craniofacial region, multiple tissue types suffer damage. These defects often involve a loss of maxillary and periorbitalarchitecture resulting in poor malar projection, orbital dystopia, and visual sequelae. These craniofacial injuries often require numerous sequentialcomplex surgeries that often do not achieve adequate aesthetic restoration or functional recovery. Therefore, there is a critical need for new solutionsand improved surgical methods to treat these injuries. 2. This work will deliver GMP grade scaffolds comprised of human bone extracellular matrix (ECM) blended with polycaprolactone (PCL) into hybridECM-PCL scaffolds that can be 3D-printed into precise anatomical structures and effectively integrated with the patients' stromal vascular fraction cellsfor the treatment of geometrically complex bone defects in craniofacial trauma, focusing on the periorbital regions. This single distinct technologydeveloped during Grant W81XWH-11-2-0022 will be integrated for this complex reconstruction of hard (bone) tissues in periorbital defects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1210202
Entities
People
- Warren L Grayson
Organizations
- Johns Hopkins University