A Novel Nonsurgical Approach to Treat Post-Traumatic Hydrocephalus
Abstract
The main objective of this exploratory proposal is to develop and validate a novel pharmacological strategy for the management of hydrocephalus caused by traumatic brain injury (TBI). Our objective in this application is to prove/refute the central role played by efflux transporters (ABCB1 and/or ABCG2) in the development of PTH. Our central hypothesis is that macromolecules are eliminated out of the brain primarily by efflux transporters (ABCB1 and/or ABCG2) and a slower clearance results in PTH due to excess macromolecules remaining in the ventricular CSF. Our experiments done so far are supportive of our central hypothesis that macromolecules are eliminated out of the brain byABCB1. Our results show that ABCB1 knockout animals had a statistically significant increased ventricular volume and increased clearance times for macromolecules compared to normal animals using intraventricular hemorrhage hydrocephalus model. ABCB1 overexpressed animals had a statistically significant smaller ventricular volume and faster clearance times for macromolecules compared to normal animals using intraventricular hemorrhage hydrocephalus model. We have performed the experiments 1 and 2 in Specific Aim 1 Genetic approach(except for the role of MRP2 deficient rats which is in progress) as well as experiments 1 and 2 in Specific Aim 2-Pharmacological manipulation. The data are being analyzed in all these groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2023
- Accession Number
- AD1210502
Entities
People
- Satish Krishnamurthy
Organizations
- State University of New York