Targeting Regulatory T Cells to Treat Chronic Migraine and Post Traumatic Headache

Abstract

In this study we propose to test the hypothesis that that reduced regulation of immune homeostasis by regulatory T (Treg) cellsat peripheral tissues contributes to the chronification of headache and cognitive impairment in chronic migraine (CM) and posttraumatic headache (PTH). The research objective is to validate Treg as a cellular target for novel, peripherally active therapy for CM and PTH, with mechanisms distinct from the existing treatment options. We made significant progress during the last funding period. First, we have found that mild traumatic brain injury (mTBI)resulted in astroglial and microglial activation in hippocampus and cortex (Aim 1A), both were inhibited by the low-dose interleukin-2 (LD-IL-2) treatment, suggesting that LD-IL-2 mitigates mTBI-induced deficit through inhibition of inflammatory responses in the brain.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2023
Accession Number
AD1210805

Entities

People

  • Yu-qing Cao

Organizations

  • Washington University in St. Louis

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Brain Injuries
  • Cells
  • Cognitive Impairment
  • Growth Factors
  • Headache Disorders
  • Hippocampus
  • Immunohistochemistry
  • Law
  • Lymphocytes
  • Maryland
  • Medical Personnel
  • Neuroglia
  • Pain
  • Peptide Growth Factors
  • Professional Development
  • Statins
  • Targeting

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology (Cancer Research).