Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep

Abstract

The present study investigated the efficacy of a non-pharmacological intervention for insomnia in 20 volunteers (aged19-39) with self-reported sleep problems. Using a counterbalanced, double-blind, crossover study design, we suppressed activation of the left lateral parietal node of the default mode network (DMN) with 40 seconds of continuous theta burst (cTBS) transcranial magnetic stimulation (TMS) versus sham. Active cTBS significantly improved polysomnographically (PSG) measured total sleep time (TST), latency to stage N3 deep sleep, sleep efficiency (SE), and sleep-based arousal index compared to sham. Within-network functional connectivity of the DMN was significantly altered by cTBS versus sham. Active cTBS also modulated DMN connectivity with other brain regions including the globus pallidus, supplementary motor cortex, and parietal operculum, which each correlated with PSG sleep outcomes.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2022
Accession Number
AD1210814

Entities

People

  • William D. Killgore

Organizations

  • University of Arizona

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Brain
  • Brain Injuries
  • Cognition
  • Cognitive Science
  • Health Services
  • Human Behavior
  • Human Factors Engineering
  • Medical Personnel
  • Minority Groups
  • Neuroimaging
  • Neuropsychology
  • Neurosciences
  • Pain
  • Psychiatry
  • Psychology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Circadian Sleep-Wake Regulation and Chronobiology
  • Neuroscience