The Impact of the Dura Mater on Prostate Spine Metastases

Abstract

Purpose: Understanding the influence of the dura and its secreted cytokines is the goal of the proposed project. Scope: We intend toexamine the effects of dura and its released cytokines on the invasion and growth of prostate cancer cells in-vitro and in-vivo and explorea possible mechanism for these effects. Major findings: Over this period, we have found that when dura is exposed to tumor that itchanges the dura and leads to increase in certain cytokines these do not significantly effect tumor growth, migration or invasion. It leadsto increase in cytokine release of il-6 and other inflammatory cytokines.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2022
Accession Number
AD1211439

Entities

People

  • Nicholas J. Szerlip

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cancer
  • Cell Line
  • Cells
  • Clinical Trials
  • Culture Media
  • Cytokines
  • Diseases
  • Dura Mater
  • Inhibitors
  • Medical Personnel
  • Michigan
  • Migration
  • Neoplasms
  • Nervous System
  • Prostate
  • Prostate Cancer
  • Spine

Fields of Study

  • Medicine
  • Physics

Readers

  • Prostate Cancer Biology.
  • Trauma Surgery or Emergency Medicine.