Polycaprolactone-collagen Composite Biomaterials for Mandible Regeneration
Abstract
Our primary objective is to demonstrate approaches to create mechanically robust, patient-customized biomaterials forlarge, load-bearing maxillofacial bone defects. To do this, we are developing approaches to integrate a biomoleculedecorated collagen scaffold with micro-scale porosity into a mechanically-robust polymeric frame generated via 3D-printingwith macro-porosity. Through the second year of this project we have completed the design, fabrication, as well asmechanical and in vitro osteogenesis testing of multiple elements of the final composite biomaterial design. We identified a PLA-collagen composite that could support robust mesenchymal stem cell (MSC) viability, osteogenic differentiation, andnew mineral synthesis while rendering it shape-fitting to improve conformal contact with the wound margin. We haveadvanced multiple strategies to incorporate biomolecular signals into the collagen scaffold via transient sequestration,covalent attachment, and through included zinc ions that enhance osteogenic activity. Ongoing efforts are completingbiomolecule incorporation and release experiments to facilitate long-term (>7 day) biomolecule bioavailability via mineralbased factor sequestration chemistries. Our efforts are essential for our goal to identify a shelf-stable, patient customizablebiomaterial that can be seeded with autologous MSCs to regenerate large CMF bone defects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2023
- Accession Number
- AD1211457
Entities
People
- Brandon Harley
Organizations
- University of Illinois Urbana–Champaign