Improving Outcomes in Prostate Cancer Based on Comorbidities: Developing Personalized Medicine

Abstract

Adverse events are common during treatment of metastatic prostate cancer, especially in elderly patients and those with comorbid medical diseases. In treatment of prostate cancer, there are several medicines that are used interchangeably and may have different rates of adverse events based on comorbidities; therefore, appropriate selection of therapies has the potential to improve outcomes. To identify adverse events associated with treatment of patients with metastatic prostate cancer and comorbid medical diseases. We will then compare rates of adverse events and survival. Aim 1. Determine the adverse events in men treated with different therapies for metastatic prostate cancer based on burden of comorbid medical disease. Aim 2. Analyze duration of therapy, treatment efficacy, and overall survival based on comorbid medical diseases, medicines and laboratory values. Aim 3. Develop an algorithm to select or alanti-androgen for metastatic prostate cancer based on based on patient comorbidities.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2023
Accession Number
AD1211464

Entities

People

  • Martin W Schoen

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Artificial Intelligence
  • Cardiac Arrhythmias
  • Cardiovascular Diseases
  • Cardiovascular Surgery
  • Cardiovascular System
  • Computational Science
  • Data Analysis
  • Data Mining
  • Databases
  • Health Services
  • Heart Diseases
  • Information Science
  • Institutional Review Board
  • Kidney Diseases
  • Medical Personnel
  • Myocardial Ischemia
  • Oncology
  • Urologic Diseases
  • Vascular Diseases

Fields of Study

  • Medicine

Readers

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  • Molecular and genetic basis of cancer.