Systematic Analysis of Genetic Mosaicism in FTD/ALS Brains

Abstract

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two closely related neurodegenerative diseases with TAR DNA-binding protein 43 (TDP-43) inclusions as a common pathological hallmark. They are characterized as age-related neurodegeneration, yet the mechanisms by which age and genetic risk interact, as well as the ultimate cause of neuronal loss, remains murky. Clinical features of FTD/ALS, including focal onset, stereotyped patterns of spread, and increased risk due to smoking, have suggested to some a role of somatic mutations as causative for some unexplained cases of FTD/ALS.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2023
Accession Number
AD1212023

Entities

People

  • Zinan Zhou

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alzheimer Disease
  • Biomedical Research
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Covid-19
  • Dementia
  • Detection
  • Diseases
  • Dna-Binding Proteins
  • Health Services
  • Inversion
  • Medical Personnel
  • Neurodegeneration
  • Neurodegenerative Diseases
  • Neuroglia
  • Parkinson'S Disease
  • Proteins
  • Sclerosis
  • Spinal Cord
  • Whole Genome Sequencing

Fields of Study

  • Biology
  • Psychology

Readers

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  • Theoretical Analysis.
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Technology Areas

  • Biotechnology