Exosome Therapy for Stabilization of Extremity Injury

Abstract

Ischemia-reperfusion (I/R) injury is a complication impacting multiple organs and tissues in the trauma setting. We tested the hypothesis that lyophilized extracellular vesicles derived from adipose stem cells could serve as an "off-the-shelf" treatment modality for I/R injury.Our in vitro studies showed that these vesicles reduced markers of I/R injury in cultured primary human muscle cells. Our in vivo (rodent) studies indicate that EVs significantly increase reperfusion; however, the increased reperfusion was also associated with a marked decrease in muscle structural proteins such as dystrophin, plectin, and obscurin.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2022
Accession Number
AD1212027

Entities

People

  • Mark W Hamrick

Organizations

  • Augusta University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biology
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Developmental Biology
  • Diseases
  • Electronic Mail
  • Extracellular Vesicles
  • Freeze Drying
  • Game Theory
  • Medical Personnel
  • Muscle Cells
  • Permeability
  • Recovery
  • Small Molecules
  • Standards
  • Stem Cells
  • Students
  • Survival
  • Therapy
  • Tissues
  • Vascular Diseases

Readers

  • Immunology and Pathology
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology