Does Prophylactic Local Tobramycin Injection Lower Open Fracture Infection Rates?

Abstract

Background: This study addresses the Clinical Trial Award (CTA) focus area of Translation of early research findings under the category of fracture related infection (FRI). Open extremity fractures (OEFs) sustained from traumatic injuries are higher risk for FRI and nonunion due to damage of the soft tissues, impaired bone vascularity and healing, and diminished host defenses against bacteria. Hypothesis/Objective: This study tests the hypothesis that administering a local dose of tobramycin injection in combination with systemic perioperative intravenous (IV) antibiotic prophylaxis will reduce the rate of FRI one year after OEF fixation surgery. This study will also determine bacterial speciation and antibiotic sensitivity among study patients who develop FRI, as well as nonunion status among all participants.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1212044

Entities

People

  • Arun Aneja
  • Jeffrey T. Foster

Organizations

  • University of Kentucky

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Bone Fractures
  • Clinical Trials
  • Department Of Defense
  • Electronic Mail
  • Health Services
  • Infection
  • Kentucky
  • Management Personnel
  • Medical Personnel
  • Monitoring
  • Organizational Structure
  • Pharmaceutical Preparations
  • Physicians
  • Professional Development
  • Standards
  • Students
  • Training
  • Wound Infections

Fields of Study

  • Medicine

Readers

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