Animal Modeling of Female Upper Reproductive Tract Infections Due to Neisseria Gonorrhoeae and Gonococcal/chlamydial Coinfection

Abstract

Pelvic inflammatory disease (PID) is a source of significant morbidity in women and is often caused by upper reproductive tract infection with the common sexually transmitted pathogens Neisseria gonorrhoeae and Chlamydia trachomatis. PID due to coinfection by these pathogens is also common. PID often goes undiagnosed due to a high proportion of asymptomatic cases and can have severe sequelae such as tubal factor infertility, ectopic pregnancy, and chronic pelvic pain. N. gonorrhoeae is associated with especially severe PID cases, but despite this, much remains unknown about gonococcal PID, partly due to a lack of animal models with which to study N. gonorrhoeae upper reproductive tract infections.

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Document Details

Document Type
Technical Report
Publication Date
Oct 05, 2020
Accession Number
AD1212213

Entities

People

  • A. C. Costenoble-caherty

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Bacterial Infections
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Coinfection
  • Health Services
  • Infection
  • Lymphocytes
  • Medical Personnel
  • Microbiology
  • Microbiomes
  • Pain
  • Sexually Transmitted Diseases

Fields of Study

  • Biology
  • Medicine

Readers

  • Analytical Chemistry
  • Infectious Disease/Epidemiology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.