Clueless Is a Novel Mitochondria-Associated Ribonucleoprotein Particle
Abstract
Mitochondria require products of mitochondrial DNA and nuclear DNA to function properly, and mutations and dysregulation of either product gives rise to mitochondrial disorders and neurodegeneration. The mechanisms which regulate import of nucleus-encoded mitochondrial proteins are not well-characterized. We have demonstrated that the protein Clueless (Clu) is required for mitochondrial function and regulation in Drosophila. Drosophila clueless mutants have systemic mitochondrialdys functions including reduced ATP levels, mitochondria with abnormal morphology and clustered localization, drastically shortened lifespans, flight muscle defects, and sterility. We have also shown that Clu is a ribonucleoprotein.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 21, 2022
- Accession Number
- AD1212252
Entities
People
- Kelsey M Sheard
Organizations
- Uniformed Services University of the Health Sciences