Quantitative Assessment of Post-Traumatic Osteoarthritis by Multimodal Optical Coherence Tomography
Abstract
Evidence from osteoarthritis (OA) studies suggests that there is a narrow time window in the early stages of the disease when cartilage can be functionally restored to reduce further degeneration. Small internal cartilage damages due to traumatic joint injuries are hard to detect with the traditional imaging technologies but pose a significant risk of inducing OA later. Our goal is to develop a non-destructive and label-free combination of optical coherence tomography (OCT) based methods for early detection of PTOA by assessment of mechanical strength, which is dependent upon both GAG and collagen, through our novel method for optical coherence elastography (OCE) based on fringe washout, and of collagen by itself through polarization-sensitive OCT. This reporting period has been the first to be uninterrupted by COVID-19-related delays. This has allowed us, for the first time to our knowledge, to track the progression of early stages of PTOA in an animal model using nondestructive optical imaging without the need for exogenous contrast agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2023
- Accession Number
- AD1212445
Entities
People
- B. H. Park
- Jin Nam
Organizations
- University of California Regents