Innate Immune Cytosolic DNA Sensors as Novel Protumorigenic Drivers in Stomach Cancer

Abstract

The majority of gastric cancer (GC) cases is associated with chronic inflammation resulting from uncontrolled activation of the body's two arms of the immune system, innate and adaptive immunity. However, current immune-based treatments for GC patients have only focused on a select few adaptive immune checkpoint inhibitors with limited clinical benefits, whereas the clinical utility of innate immunity remains underexplored in GC.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2023
Accession Number
AD1212450

Entities

People

  • Brendan J. Jenkins
  • Ruby Dawson

Organizations

  • Monash University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Gene Expression
  • Gram-Negative Bacterial Infections
  • Health Services
  • Immune System
  • Intestinal Diseases
  • Lymphocytes
  • Medical Personnel
  • Mucous Membrane
  • Neoplasms

Fields of Study

  • Medicine

Readers

  • Molecular Genetics
  • Oncology