Blood-Based Biomarkers of Traumatic Brain Injury and Related Vascular Dementia

Abstract

This study focuses on the association of traumatic brain injury (TBI) exposure with blood, neuroimaging, and cognitive biomarkers of TBI, traumatic cerebral vascular injury (TCVI), and cerebrovascular dysfunction. TCVI is a frequent consequence of TBI and may underlie a significant portion of chronic disability following TBI, including the risk of progression to vascular dementia. The study aims to characterize these unique biomarkers as well as their relationship to TBI history. It also aims to assess their ability to predict cognitive decline and changes in structural neuroimaging. Study agreements are still in progress and recruitment will soon begin.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1212488

Entities

People

  • Sara M Lippa

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Biological Markers
  • Biomedical Research
  • Brain Injuries
  • Data Analysis
  • Dementia
  • Department Of Defense
  • Maryland
  • Medical Personnel
  • Military Medicine
  • Natural History
  • Neuroimaging
  • Patent Applications
  • Procurement
  • Professional Development
  • Technology Transfer
  • Training

Fields of Study

  • Medicine
  • Psychology

Readers

  • Clinical Trial Research.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.