Exposure to Non-Steady-State Oxygen is Reflected in Changes to Arterial Blood Gas Values, Prefrontal Cortical Activity, and Systemic Cytokine Levels
Abstract
Onboard oxygen generating systems (OBOGS) provide increased inspired oxygen (FiO2) to mitigate risk of neurologic injury within high altitude aviators. When operating in the 'Normal' mode, OBOGS delivers highly variable oxygen concentrations that may oscillate around a predetermined FiO2 set point, even when the aircraft cabin altitude is relatively stable. Steady-state exposure to 100 FiO2 evokes neurovascular vasoconstriction, diminished cerebral perfusion, and altered electroencephalographic (EEG) activity. Whether non-steady state FiO2 exposure leads to similar outcomes is unknown. This study's objective was to characterize physiologic responses to both steady state and non-steady state FiO2 exposure during normobaric and hypobaric environmental pressures emulating cockpit pressures within tactical aircraft.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 29, 2023
- Accession Number
- AD1212803
Entities
People
- Alireza Abdollahifar
- David S. Burch
- Elizabeth G Damato
- Joseph J. Piktel
- Kingman P Strohl
- Lily K. Norton
- Michael J. Decker
- Seth J. Fillioe
- Seunghee P. Margevicius
Organizations
- Air Force Research Laboratory
- Case Western Reserve University
- Cuyahoga Community College
- University at Buffalo