Development and Validation of a Novel Specialized Proresolving Mediators (SPM) Therapy to Counter Blast-Related Eye Injuries
Abstract
This proposed research project meets the intent of FY19 VRP IIRA and aligns with the Focus Areas: Eye injury or visual dysfunction as related to a military-relevant traumatic event due to blast exposure and Diagnosis and treatment of eye injuries in austere environments and prolonged field care settings. The rationale for this proposal is based on the expected change in guidelines for combat eye care due to prolonged field care scenarios. Soldiers that have experienced closed globe injuries and visual system impairments after blast or to blast-related traumatic brain injury (TBI) are transferred to higher levels of care until the appropriate provider and capabilities are available. In potential future conflicts, delays in medical evacuation are expected, which will impact the ability to provide combat casualty care using current ocular trauma protocols. Visual dysfunction without severe ocular injuries are very common with blast-related TBI and can result from a myriad of causes to include direct damage to the retina, optic nerve and other neurosensory CNS structures of the brain. The objective of the proposed study is to examine the deficit on the visual system drive by blast injury, and the basis of the specialized pro-resolving lipid mediators (SPMs) as neuroprotective therapeutic interventions to mitigate tissue damage, neuroinflammation, and ameliorate visual deficit caused by blast exposure. Blast exposure causes retinal and optic nerve injury, which in turn leads to neuroinflammation as seen by increased inflammatory mediators, gliosis (microglial and astrocyte activation) and apoptosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2023
- Accession Number
- AD1212965
Entities
People
- Jose D. Rios
Organizations
- Geneva Foundation