Vitamin D Deficiency Leads to Increased Intraprostatic Hormones in African American Men

Abstract

Our most significant finding for this project is the profound defect in prostate hormone levels in megalin knockout mice. This ties in with our prior finding that vitamin D regulates megalin, demonstrating a link between vitamin D a prostate hormones for the first time. We have also focused in HSD17B7 as a key gene differentially expressed by African Ancestry.HSD17B7 is a key enzyme for estrogen metabolism and we found that it is higher in AA prostate stroma on a TMA. Further, HSD17B7 expression is increased by estrogen and androgen inpatient-derived stromal cells, validating the microarray data. There is one paper in revision and another in preparation from this work.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2022
Accession Number
AD1212980

Entities

People

  • Larisa Nonn

Organizations

  • University of Illinois at Chicago

Tags

DTIC Thesaurus Topics

  • Acquisition
  • African Americans
  • Biomedical Research
  • Cells
  • Data Analysis
  • Gene Expression
  • Hormones
  • Illinois
  • Internet
  • Medical Personnel
  • Neoplasms
  • Nutrition Disorders
  • Prostate Cancer
  • Sex Hormones
  • Statistical Analysis
  • Students
  • Vitamin D

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.