The Role of NADPH Oxidase1 (NOX1) in the Colon in Rotenone-Induced A-Synuclein Pathology Propagation Along the Gut-Brain Axis

Abstract

The proposed study will investigate how Nox1-derived ROS contributes to early-stage alpha-SYN aggregation in the gut using a cell-to-cell alpha-SYN propagation assay and gut cell-specificNox1 deleted mice model. We will also test a potent and selective Nox1 inhibitor, ML171, in our gut-brain PD model. Successful completion of the project will elucidate the molecular mechanisms underpinning how alpha-SYN aggregation is initiated in the gut and to what extent Nox1 plays a role in this Mprocess. Moreover, the proposed study could identify a specific Nox1 inhibitor as a novel therapeutic intervention to prevent gut-driven PD development.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2023
Accession Number
AD1212985

Entities

People

  • Yoon-seong Kim

Organizations

  • Rutgers University–New Brunswick

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain
  • Brain Stem
  • Culture Techniques
  • Demographic Cohorts
  • Department Of Defense
  • Electronic Mail
  • Heterocyclic Compounds With 4 Or More Rings
  • Information Operations
  • Inhibition
  • Inhibitors
  • Maryland
  • Monitoring
  • New Jersey
  • Oxidative Stress
  • Pathology
  • Smooth Muscle
  • Universities

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Oncology