Mechanisms of Metastasis Suppression and Translational Applications in Thyroid Cancer

Abstract

Progressive metastases are responsible for most deaths from thyroid cancer. We have identified that loss of RCAN1.4 is a key event in metastatic progression due to increased NFE2L3-mediated IL-8 expression and by inducing a tumor-promoting immune environment. The IL-8 system is not able to be studied in mouse models and the pace of translation to define regulatory mechanisms regulating metastatic progression in immune competent systems requires arduous mouse models that delay translational efficiency. To test the role of IL-8 and RCAN1.4 loss and to model the tumor: immune interface in a human cell based model with more rapid translational potential, we will develop a highly reproducible thyroid cancer metastasis on a chip platform that will enable mechanistic studies of the RCAN 1.4 metastasis suppression pathway, create a new platform to study mechanistic regulation of the tumor-immune interface, and allow for more rapid validation of biomarkers and therapeutic targets.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2023
Accession Number
AD1212988

Entities

People

  • Aleksander Skardal
  • Matthew D Ringel

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • Biological Staining And Labeling
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cancer
  • Cell Biology
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Leukocytes
  • Lymphocytes
  • Medical Personnel
  • Neoplasms
  • Prostheses And Implants
  • Rna Sequence Analysis
  • Three Dimensional
  • Tissues
  • Two Dimensional
  • Universities

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).