Chromatin Accessibility and the Convergent Oncogenic Pathways of Angiosarcomas
Abstract
Angiosarcoma is a rare type of soft tissue sarcoma, with a prevalence of fewer than 300 cases in the US annually. Our understanding of the oncogenic mechanisms of aggressive angiosarcomas is rudimentary, and our ultimate goal is to develop appropriate and effective treatment options and protocols for patients with this disease. Angiosarcoma are genomically complex; however, they share a histological morphology that consists of disorganized, malignant vessel-forming cells. Our hypothesis is that chromatin accessibility is necessary to establish the mutational landscape, which consequently activates convergent signaling pathways that contribute to angiosarcoma development. In this report period, we established chromatin accessibility and the transcriptomic landscape in TP53 mutant hemangioblast cells differentiated from human induced pluripotent stem cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2023
- Accession Number
- AD1213000
Entities
People
- Jong Hyuk Kim
Organizations
- University of Florida