Use of Tranexamic Acid to Reduce Tissue Edema and Prevent Burn Wound Conversion
Abstract
The purpose of the experiments performed during the past year was to elucidate the effect of tranexamic acid (TXA) on burn wound conversion in a rat burn wound conversion model. The comb burn injury model is well validated in the literature for this purpose particularly at 7 days post injury which represents the gold standard for this experiment. Our studies clearly demonstrated that burn wound conversion was reduced by treatment of rats within traperitoneal (IP) TXA at this time point. Furthermore, TXA demonstrated efficacy at 24, 48 and 72 hours after comb burn injury. Additionally, we were able to demonstrate that less mitochondrial DNA an established marker of tissue damage was reduced at 24 and 48 hours. This finding indicates that TXA has significant cell protecting activity. Experiment #2 demonstrated that these protective effects were maintained with a more severe concomitant burn injury and that tissue regeneration was significantly upregulated. Burn-induced SIRS was also down regulated and tissue edema as well as pulmonary inflammation reduced. These findings clearly demonstrate that Tranexamic acid reduces burn wound conversion and has cell protective properties in the rat burn wound conversion model when compared to no treatment. In the context of severe burn injury, TXA reduces SIRS, burn wound conversion, tissue edema, capillary leak and pulmonary infiltration. Our findings suggest TXA may be an ideal therapy for burn injured warfighters in the forward deployed setting.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2023
- Accession Number
- AD1213437
Entities
People
- Damien Carter