A Rapid and Simple Blood Test to Identify Gastrointestinal Inflammation in Children with ASD

Abstract

The primary goal of this proposal is to develop a rapid blood test for ASDEC by refining and validating the previously published diagnostic biomarker of this ASD phenotype. In SA1 we proposed to refine the putative peripheral blood-base gene expression signature for ASDEC by incorporating whole blood gene expression profile data from both ASD and TD children without GI symptoms. In SA2 we proposed using the validated transcripts from Aim 1 to generate a predictive model in the cohort for Aim 1. We will then test the performance of the predictive model in a new set of 200 ASD GI and 200 ASD no-GI. In Y2, we are largely on target with our progress as we have completed Major Task 1 and Subtasks 1-5, except for Subtask 3 (because collection of blood samples from this cohort {ASD w/o GI symptoms} was only recently completed).

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2023
Accession Number
AD1213446

Entities

People

  • Stephen J. Walker

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Autism
  • Biological Markers
  • Biomedical Research
  • Cells
  • Chemical Reactions
  • Clinical Trials
  • Data Analysis
  • Department Of Defense
  • Diseases
  • Electromagnetic Fields
  • Electronic Mail
  • Gene Expression
  • Genes
  • Hematologic Tests
  • Inflammation
  • Medical Personnel
  • Microbiomes
  • Pain
  • Phenotypes
  • Polymerase Chain Reaction
  • Predictive Modeling
  • Procurement
  • Therapy

Fields of Study

  • Biology

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Clinical Trial Research.
  • Molecular Genetics