Identification and Utilization of Upper Motor Neuron Biomarkers for ALS
Abstract
This proposal is a collaborative effort between (a) a clinical team at Massachusetts General Hospital/Harvard Medical School, who have created the worlds largest platform for ALS clinical trials; and (b) a multi-disciplinary team at Northwestern University, composed of scientists who have developed ways to detect proteins in blood with unprecedented precision and clarity, and scientists who have extensive knowledge of the biology of upper motor neurons (UMN) and their role in ALS. This multi-institutional team will apply its expertise and resources towards the goal of identifying UMN biomarkers in ALS. These studies will be used to determine whether specific patterns of protein in blood can be used to diagnose ALS, develop more precise and sensitive clinical trials, and provide a reliable measure of the impact of treatment on the cortical component of ALS more quickly and accurately. The development of biomarkers for UMN degeneration has the potential to substantially improve the diagnosis, treatment and prognosis of individuals with ALS.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1213461
Entities
People
- Hande Ozdinler
Organizations
- Northwestern University