Brainwide Social Network in Mice Underlying Autism Spectrum Disorder
Abstract
Social interactions are a crucial part of our human identity and its dysfunction is a core symptom in autism spectrum disorder (ASD). However, the neuronal circuits and their causal underpinnings remain unclear, displaying inconsistent results across studies, partially due to the large heterogeneity of ASD. It is thought that ASD individuals have an underdeveloped Theory of Mind (ToM), unable to grasp the mental states of others, leading to social impairment. Human imaging studies have outlined several key brain areas that are socially-related. Nevertheless, these studies mostly discard individual differences and fail to capture fast network dynamics during real-time and natural social interactions. Alternatively, animal models enable neuronal recordings from freely moving individuals, but usually focus on one or two areas, lacking a brain-wide measurement. Furthermore, similar to human studies, mice are rarely studied at the individual level. To address these limitations, we have developed a multi-fiber method that enables simultaneous recording from dozens of brain areas of freely behaving mice. The proposal studies the personal brain-wide social networks dysfunctions in ASD.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2023
- Accession Number
- AD1213463
Entities
People
- Ariel Gilad
Organizations
- Hebrew University of Jerusalem