Strategies to Augment Ketosis (STAK) for Enhanced Readiness and Disease Reversal

Abstract

This project is focused on a unique nutrition-based intervention we refer to as Strategies To Augment Ketosis (STAK) that is designed to broadly address the surging problem of poor metabolic health in many service members and the general population. The STAK program represents the most comprehensive assessment of different methods of achieving physiological levels of ketones (nutritional ketosis) through newly developed ketone esters and well-formulated ketogenic diets. The four proposed research projects encompassing 7 human research studies are being carried out by a highly multidisciplinary team of experts who will provide foundational knowledge on methods of optimizing nutritional ketosis, and the potential role of STAK to improve readiness in response to sleep restriction and improve therapeutic management in individuals with heart failure and polycystic kidney disease. During this first year of the program the primary activities have focused on team communication, research logistics, and ethics and regulatory approvals. We have made significant progress and are now in a position to begin participant recruitment for these studies during Year 2.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1213473

Entities

People

  • Jeff Volek

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Department Of Defense
  • Employment
  • Health Services
  • Heart Failure
  • Heart Rate
  • Institutional Review Board
  • Kidney Diseases
  • Liquid Chromatography
  • Management Personnel
  • Mass Spectrometry
  • Medical Personnel
  • Musculoskeletal Physiology
  • Professional Development
  • Students
  • Test Methods
  • Therapy

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Systems Analysis and Design
  • Team-Based Human-Centered Cognitive Task Decision Making and Information Performance.