Precision Oncology-Based Therapeutic Targeting in Mesothelioma
Abstract
Given that mesothelioma nearly universally exhibits cell cycle abnormalities and the cell cycle interacts with multiple pathways important to the growth of mesothelioma, disruption of the cell cycle presents as a likely effective approach (or will contribute to a multiple pathway-targeted combination approach) to treating mesothelioma clinically. Our hypothesis is that combined inhibition of 1) multiple cell cycle proteins, and 2) one of 3 separate and alternative molecular pathways will serve as an effective therapy against multiple molecular subtypes of mesothelioma. Scope: We are utilizing in vitro and in vivo studies to evaluate how to best target molecular subtypes of mesothelioma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2023
- Accession Number
- AD1213965
Entities
People
- Mark Klein
Organizations
- Veterans Administration Medical Center