Personalized Targeted Nutrition via StructurEd Nutrition Delivery Pathway to Improve Recovery of Physical Function in Trauma- SeND Home
Abstract
The SeND Home initiative targets ICU-Acquired Weakness (ICU-AW), a condition that compromises physical function and life quality in trauma survivors. This problem stems from two factors: a catabolic state due to injury and critical illness, and malnutrition often worsened by surgical and gastrointestinal issues. SeND Home offers a personalized early parenteral nutrition (PN) regimen, drawing on data from the LEEP-COVID study and aligning with international ICU nutrition guidelines. Implemented in the ICU, the program employs Q-NRG indirect calorimetry for precise caloric assessments and extends into post-discharge, facilitated by registered dieticians. The study aims to execute a Phase II Randomized Controlled Trial to evaluate SeND Home against conventional care, focusing on physical function, muscle mass, and life quality. Three specific objectives outline this focus: assessing physical and muscle parameters, examining life quality and clinical markers like hospital stay length and infection rates, and investigating mitochondrial function and resilience biomarkers. SeND Home has broad clinical implications, extending its relevance to military settings. Its nutritional strategies can be deployed in hospital ICUs and field care, addressing nutritional deficiencies in trauma patients. As abdominal injuries are prevalent in modern conflicts, SeND Home could markedly improve military personnel's recovery and readiness.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1213970
Entities
People
- Krista Haines
- Paul E Wischmeyer
- Sean Montgomery
- Suresh Agarwal
Organizations
- Duke University