Optimization of an Acute Care Strategy to Stabilize Composite Tissue Injuries and Facilitate Improved Functional Outcomes for Accelerated Return to Duty
Abstract
In this study, we hypothesized that treating a volumetric muscle loss (VML) defect with a customized muscle void filler will improve bone healing and muscle strength recovery in pigs subjected to VML with our without an adjacent segmental bone defect (SBD). We are testing the customized void filler in minipigs with isolated VML defects and in pigs with composite tissue injuries (CTI) that include the VML with a SBD. Control animals will have either a VML or CTI injury but no void filler. Experimental animals will have either a VML or CTI injury and will have the muscle defect fill with void filler at the time of the injury. All pigs with have muscle autografting 28 days after the original injury. To date, 7 CTI and 3 VML controls have been enrolled. Six (3 CTI and 3 VML) specimens have proceeded to euthanasia. All animals have tolerated surgery. Muscle testing and bone healing are comparable on our first six specimens to our previous work. Additional pigs will be delivered in December. Biochemical and histological analyses are pending.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2023
- Accession Number
- AD1214520
Entities
People
- Christopher L Dearth
- Todd O McKinley
Organizations
- Indiana University