Evaluation of Clinically Relevant Prognostic Indicators in a Model of Mild TBI/Concussion

Abstract

Closed head concussion is of significant concern to both military and civilian medicine. While acute concussion symptoms resolve for most patients, a subset will experience effects that persist chronically. Emphasis has been placed upon identifying prognostic indicators to distinguish these vulnerable patient populations for the purpose of providing enhanced care. Two potential clinically-relevant prognostic indicators include altered brain glucose metabolism as detected by FDG-PET imaging and changes in serum microRNA levels. This aim of this work is to comprehensively characterize longitudinal profiles of these two potential prognostic indicators following single and repeated injuries in a rodent model of closed head concussion. These studies utilize the WRAIR Projectile Concussive Impact (PCI) model, which is a military relevant model of closed head concussion developed under the directive of the Combat Care Casualty Research Program (CCCRP). In this Close Out Report, we provide a summary of all results/deliverables from experiments conducted under this project.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2022
Accession Number
AD1214655

Entities

People

  • Deborah A. Shear

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Brain
  • Brain Injuries
  • Correlation Analysis
  • Craniocerebral Trauma
  • Data Analysis
  • Detectors
  • Hemorrhagic Shock
  • Information Processing
  • Medical Personnel
  • Neurosciences
  • Oxygenation
  • Physiological Monitoring
  • Thalamus
  • Vulnerability

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