Establishing Network Connectivity and Microvascular Imaging Biomarkers for Tuberous Sclerosis Complex

Abstract

Tuberous Sclerosis Complex (TSC) often results in the development of tubers that vary widely among patients in number, size, and location. Often, the presence of these tubers results in seizures, but epilepsy phenotype can vary with no clear association with number of tubers. The challenge for TSC surgical treatment is the usual presence of multiple tubers. There is clear need for tuber biomarkers that can identify and potentially predict epilepsy phenotype and cognitive outcomes. This project applies advanced imaging techniques to extract functional network connectivity features of tuber arrays in patients that associate with epilepsy and cognitive phenotypes. Importantly, the project will also use imaging to ascertain microvascular density and topology from individual tubers to help distinguish those that impact seizure activity and cognition.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2023
Accession Number
AD1214657

Entities

People

  • Mark DiFrancesco

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Biological Markers
  • Biomedical Research
  • Data Acquisition
  • Department Of Defense
  • Diseases
  • Epilepsy
  • Health Services
  • Hospitals
  • Imaging Techniques
  • Instructions
  • Maryland
  • Medical Personnel
  • Networks
  • Phenotypes
  • Pipelines
  • Professional Development
  • Sclerosis
  • Surgery

Fields of Study

  • Medicine

Readers

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