Dietary Polyunsaturated Fatty Acids, Inflammatory Index, and Circulating Endocannabinoids/Oxylipins in Relation to Colorectal Carcinogenesis in Black Women
Abstract
This study aims to determine the role of dietary inflammation and circulating lipid mediators in colorectal carcinogenesis among Black women. Data and blood specimens for this study have been previously collected in the Black Women's Health Study, a prospective cohort of 59,000 Black women. To examine the role of dietary inflammation, including polyunsaturated fatty acids and fish intake, we are using data from food frequency questionnaires (Aim 1). To examine lipid mediators, we are conducting targeted assays using liquid chromatography/mass spectrometry to quantify levels of endocannabinoids and oxylipins in plasma samples (Aim 2). Finally, we will then leverage the published literature to assess the contribution of polyunsaturated fatty acids and fish intake to racial disparities in colorectal cancer and adenoma risk (Aim 3). This project consists of selecting appropriate individuals with dietary data and/or blood samples available, accessing samples for biospecimen assays, meta-analyzing the literature, and conducting analyses. To date, we have created data sets and started data analysis for Aim 1, we have selected individuals with blood samples available for Aim 2, and we have begun the systematic review of the literature for Aim 3. Analysis is ongoing; we have no results to present at this time.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2023
- Accession Number
- AD1215417
Entities
People
- Jessica Petrick
- Nuo Xu