Cell-Free Synthetic Biology and Biofabrication for Novel Silk Biomaterials Development
Abstract
Developing novel materials with tailored properties/functionalities remains a grand challenge. In nature, biology has offered enormous illustrations on precision molecular design and self-assembly that are incomparable to the conventional top-down design scheme. An emerging branch of research discipline to recapitulate or adapt the bioinspired material design and fabrication is called biomimicry. To succeed in biomimetic material fabrication, synthetic biology that synergizes engineering and biology has come to play a pivotal role. Synthetic biology (SynBio) enables programming of biological matters, such as proteins or polymers, in a fashion that materials by design can be readily achieved and render novel and yet desirable material properties through a bottom-up fabrication process. Our broad goal is to innovate the design, synthesis, and fabrication regimes of creating advanced biomaterials via the power of synthetic biology, which, in turn, could drastically change the landscape of developing future bioinspired materials. Taking the advantage of spider silk, the ultimate performance biomaterial, as our blueprint scaffold for of engineering the next generation of silk materials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 25, 2023
- Accession Number
- AD1215800
Entities
People
- Hsuan-Chen Wu
Organizations
- National Taiwan University