Simulating the Effects of Austere Hot and Humid Conditions on Anesthetics and Antibiotics Used in Military Dentistry and Oral Surgery
Abstract
Dental restorations and oral-facial surgeries rely heavily on pharmaceuticals for successful treatment. Local pain management is essential in dental restorations and general anesthesia is the cornerstone of more invasive oral-facial surgeries. For recovery, a similarly important focus is infection prevention with the use of antibiotics. Some pharmaceuticals are known to be susceptible to degradation above room temperature, while the temperature-related drug degradation profiles of others are unknown. The U.S. military operates in a variety of environments, including conditions not anticipated by manufacturers of civilian dental supplies or devices. We achieved our objective by artificially inducing degradation through simulated austere conditions in an environmental chamber for 10 days. Liquid Chromatography-Mass Spectrometry was then used to compare the degradation of these pharmaceutical compounds that were environmentally stressed to those stored at manufacturer recommended conditions. All drugs in this study exhibited degradation less than 10 percent, and only three experienced more than 5 percent.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 03, 2023
- Accession Number
- AD1215924
Entities
People
- Al Tiba
- Daniel Arens
- Daniel W. Thompson
- Drew Havard
- Eun Y. Huh
- Meaghan Rose
- Wen Chen
- Yoon Y. Hwang
- Zachary Mcintosh
Organizations
- Naval Medical Research Unit—San Antonio