Testing a Chitosan-Derived Hydrogel as a Drug Vehicle to Control Bleeding and Promote Wound Healing
Abstract
Traumatic hemorrhage remains the leading cause of preventable deaths of warfighters. In the field, wound dressings that initiate coagulation and a systemic dose of tranexamic acid are the preferred method to control bleeding until a casualty can be transported to a hospital. Due to foreseen peer or near-peer threats, a 72-hour timeline for point-of-injury care has been established as the new goal for field stabilization. For this reason, there is a need to support long-term coagulation and prevent sepsis. In this project, we investigated a chitosan-derived hydrogel as a vehicle for delivering a novel coagulation therapeutic cocrystal. The hydrogel we tested reduced clot strength and increased the time to form the clot. For these reasons, we determine that it would not make a suitable vehicle for drug delivery to support hemostasis, especially in a trauma situation. The tranexamic acid-gallic acid cocrystal did show potential benefits and requires further examination.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 03, 2023
- Accession Number
- AD1215928
Entities
People
- Al Tiba
- Alexei V Tivanski
- Daniel W. Thompson
- Eun Y. Huh
- Leonard Macgillivray
- Yoon Y. Hwang
- Zachary Mcintosh
Organizations
- Naval Medical Research Unit—San Antonio
- University of Iowa