UTE MRI: A Novel Biomarker for Remyelination in Multiple Sclerosis Patients

Abstract

Hypothesis UTE MRI can be applied to MS patients undergoing myelin repair therapy and provide specific measurements of myelin non-invasively across the entire brain. Objectives Apply UTE MRI to MS patients undergoing remyelinating therapy; analyze the imaging results in comparison to electrophysiology, in known lesions, and across the white matter Rationale The scientific premise of this proposal is that the capability of UTE MRI to directly measure signals from the myelin phospholipid membranes has the potential to transform non-invasive assessment of myelin by providing a more specific measurement of myelin density and structure.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2023
Accession Number
AD1216075

Entities

People

  • Peder Larson

Organizations

  • University of California Regents

Tags

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • California
  • Central Nervous System
  • Clinical Trials
  • Data Analysis
  • Electronic Mail
  • Electrophysiological Phenomena
  • Electrophysiology
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Multiple Sclerosis
  • Nervous System
  • Patent Applications
  • Statistical Analysis
  • Students

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Neuroscience