Validation of a Multi-Use Scalable, Long-Acting Nanoparticle Anesthetic Tilapia Dressing for Complex Burn Trauma
Abstract
Objective: The proposal goal is to identify the novel topical long-acting lidocaine nanoparticle anesthetic Dressing (NPD) optimal safe dosing strategy by examining its pharmacokinetic safety profile and efficacy. Specific Aim 1 further characterizes and develops the physicochemical properties of NPD, with and without collagen targeting ligand and determine the cold chain logistics, optimal dosing and administration for application of the NPD to a burn wound. Specific Aim 2 evaluates the efficacy and safety of the NPD applied to an acute burn wound by evaluating pain and pharmacokinetics in a pig burn model after application of the NPD to optimize dosing. Study Design: In Aim 1 we will synthesize and characterize the NPD, with and without collagen targeting ligand and then determine the cold chain logistics, optimal dosing and administration strategies for application of NPD to burn wounds. Aim 2 will evaluate pain in a 10 percent pig burn model treated with different doses of the NPD to assess pharmacokinetics and assure efficacy for pain, wound colonization, and healing.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1216080
Entities
People
- Jamie Peyton
- Kit Lam
- Tina Palmieri
Organizations
- California State University, Sacramento