ProBIOPTIC: Protein Biomarkers to Inform Optimization of PTSD Therapeutics to Inform Clinical Trials
Abstract
This project aims to address the understanding of biological factors contributing to an individuals long-term outcomes following atraumatic event by investigating how blood biomarkers relate to posttraumatic stress disorder (PTSD) symptom presentation following atraumatic event in Service Members and Veterans (SMVs). Through novel analysis of brain derived exosomes from existing blood samples, we can measure brain related messaging and activities by their protein-rich cargo. Enhanced understanding of the biological underpinnings of PTSD symptom clusters will help identify targeted treatments for personalized interventions based on the dysregulated pathway identified, and can also serve as predictive biomarkers for PTSD. The project aims to determine protein profiles and protein networks associated with participants with PTSD compared to those without PTSD, using SOMAscan technology. It also aims to determine protein profiles and networks associated with each of the four PTSD symptom clusters, through SOMAscan technology, and hopes to validate these determined protein profiles. This study has obtained full approval and is awaiting the completion of legal agreements before analyses can begin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1216101
Entities
People
- Jessica Gill
Organizations
- Johns Hopkins University