CHD1-Deficiency Engenders a Distinct Epigenetic Profile in Castration-Resistant Prostate Cancer

Abstract

This proposal will examine the role one of the most frequent gene alterations, in CHD1 (Chromodomain-helicase DNA binding protein 1), plays as a driver of cancer. We will test whether it alters a series of enzymes that may be targets for cancer therapy. This proposal postulates that a tumors genomic profile can be used to predict the types of epigenetic alterations seen in CRPC. This proposal tests if the genetic status of a gene encoding an epigenetic modifying protein commonly deleted in PC, Chromodomain helicase-DNA-binding protein 1 (CHD1), predicts a unique epigenetic profile.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2022
Accession Number
AD1216102

Entities

People

  • Joseph Gawdzik

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Deficiencies
  • Department Of Defense
  • Genes
  • Genetics
  • Institutional Review Board
  • Medical Personnel
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • United States
  • Universities
  • Wisconsin

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Oncology
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology