Nuclear Receptor NR4A2/Nurr1 as a Therapeutic Target for Neurotoxic Injury in Parkinson's Disease

Abstract

Environmental exposures are closely linked to the development of Parkinson's disease (PD). A number of environmental compounds have been implicated as risk factors for PD, including heavy metals, pesticides and anti-cholinergic chemical warfare agents. A central mechanism of action of many of these agents is the capacity to inhibit mitochondrial energy production in cells, leading to several common pathways of cellular dysfunction associated with PD, including protein misfolding, inflammation and injury to nerve cells in the brain that regulate movement. It is now known that veterans of the 1991 and more recent Gulf wars were widely exposed to a number of these agents, particularly pesticides, that has increased the prevalence of PD and PD-like disorders amongst Gulf war service veterans. It is therefore critical to identify both the cellular mechanisms driving this pathology as well as key signaling pathways that could be therapeutically targeted to interdict further neurological decline in individuals diagnosed with parkinsonism related to environmental exposures.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2023
Accession Number
AD1216503

Entities

People

  • Ronald B Tjalkens
  • Savannah Rocha
  • Srijana Upadhijay
  • Stephen Safe

Organizations

  • Colorado State University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Brain
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Culture Media
  • Culture Techniques
  • Department Of Defense
  • Diseases
  • Elements
  • Environmental Exposure
  • Heavy Metals
  • Neuroglia
  • Neurons
  • Parkinson'S Disease
  • Persian Gulf Syndrome
  • Three Dimensional

Readers

  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.